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Manchester United travel to Spain looking to seal a quarter-final berth in the Europa League Round of 16 ties.
The Red Devils are the clear favourite after clinching an emphatic 4-1 win in the first-leg match at Old Trafford.
And anything defeat would be a disaster for Manchester United as the match draws close by the minute.
Following the upcoming game slated to take place in Spain, we take a look at the possible eleven players that could start for Manchester United in this match.
The Red Devils are not expected to make any changes at the back four from the side that drew goalless with Southampton earlier on Sunday.
David de Gea should be in goal for Manchester United while Portuguese right-back Diogo Dalot could come in for Aaron Wan-Bissaka.
English star Jadon Sancho could be the one to drop to the bench in order to make way for a midfielder to come into the starting line-up possibly in the form of Fred.
In the attack, Dutch striker Wout Weghorst is likely to come into the starting team. He is expected to lead the charge for goals for Manchester United.
Manchester United’s possible eleven against Spanish side Real Betis
David de Gea; Diogo Dalot, Raphael Varane, Lisandro Martinez, Luke Shaw; Casemiro, Fred; Antony dos Santos, Bruno Fernandes, Marcus Rashford; Wout Weghorst.